CLDN6/CLD6 Antibody

SKU: orb1805484

Description

Anti-CLDN6 Reference Antibody is expressed from CHO. The heavy chain type is IgG1, and the light chain type is hukappa. It has a predicted MW of 150kDa.

Images & Validation

• Tested Applications: ELISA, FA, FACS, In vivo
• Reactivity: Human

Key Properties

• Clonality: Monoclonal
• Target: CLDN6 / CLD6
• Source/Expression System: CHO
• Molecular Weight: 145.84 kDa
• Purity: >95%
• Purification: Protein A
• Endotoxin: <0.001 EU/ug

Storage & Handling

• Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Buffer/Preservatives: 100 mM Proline/Acetic acid 20mM Arginine pH 5.0
• Concentration: Batch dependent
• Disclaimer: For research use only

Anti-CLDN6 Reference Antibody (DS-9606a) on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

The purity of Anti-CLDN6 Reference Antibody (DS-9606a)is more than 99.37% ;determined by SEC-HPLC.

Immobilized human CLDN6 VLP Protein at 2 μg/mL can bind Anti-CLDN6 Reference Antibody (DS-9606a);EC50=0.00407 μg/mL.

Human CLDN6 CHO cells were stained with Anti-CLDN6 Reference Antibody (DS-9606a) and negative control protein respectively; washed and then followed by PE and analyzed with FACS; EC64=3.036 nM.

DS-9606a by huCLDN6-HEK293 increased with the increase of antibody concentration; and the Internalization Rate (%) reached 60% at antibody concentration of 1 nM.

DS-9606a inhibited the tumor growth of PA-1 on Balb/c nude mice. The result showed significant anti-tumor effects; with an tumor inhibition rate (TGI) of 84.7% at 5 mpk at D46.

Quick Database Links

Gene Symbol

CLDN6 / CLD6

UniProt

P56747