Val-Cit-PAB-DEA-Duo-DM

SKU: orb2664646

Description

Val-Cit-PAB-DEA-Duo-DM is a key component for constructing antibody-drug conjugates (ADCs), integrating the protease-cleavable Val-Cit-PAB linker, a DEA spacer, and the potent cytotoxic agent Duocarmycin DM. This conjugate is widely used in research for developing targeted cancer therapies and has been evaluated in both in vitro cytotoxicity assays and in vivo xenograft models.

Key Properties

• CAS Number: 1698870-53-9
• MW: 983.55
• Formula: C₅₀H₆₃ClN₁₀O₉
• SMILES: C(Cl)[C@H]1C2=C(N(C(=O)C3=CC=4C(N3)=CC=C(OCCN(C)C)C4)C1)C=C(OC(N(CCN(C(OCC5=CC=C(NC([C@@H](NC([C@H](C(C)C)N)=O)CCCNC(N)=O)=O)C=C5)=O)C)C)=O)C=6C2=CC=CC6
• Target: Drug-Linker Conjugates for ADC

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

118016492