Tz-Thalidomide

SKU: orb1944675

Description

Tz-Thalidomide is a bifunctional molecule combining a tetrazine group with a thalidomide-based E3 ligase ligand. It exhibits affinity for BRD4 and is primarily used in chemical biology for targeted protein degradation studies, including PROTAC development and bioorthogonal labeling in cellular assays.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2087490-42-2
• MW: 571.58
• Purity: 98.34% (May vary between batches)
• Formula: C₂₉H₂₉N₇O₆
• SMILES: O=C1NC(=O)C(N2C(=O)C=3C=CC=C(OCCCCCC(=O)NCC=4C=CC(=CC4)C5=NN=C(N=N5)C)C3C2=O)CC1
• Target: Epigenetic Reader Domain,Molecular Glues,PROTACs
• Solubility: DMSO:40 mg/mL (69.98 mM)

Bioactivity

• Target IC50:
  BRD4(1):46.25 μM|BRD4(2):62.55 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BRD4, Epigenetic Reader Domain, EpigeneticReaderDomain

Compound Identifiers

PubChem CID

132211963