SJ 11646

SKU: orb1979943

Description

SJ 11646 is a potent, dasatinib-based PROTAC degrader of lymphocyte-specific protein tyrosine kinase (LCK) with a phenyl glutarimide cereblon binder. It demonstrates potent cytotoxicity in LCK-activated T-ALL cell lines and primary samples in vitro and shows anti-leukemic efficacy in patient-derived xenograft models in vivo, supporting its study in T-cell malignancy research.

Key Properties

• MW: 746.28
• Formula: C₃₆H₄₀ClN₉O₅S
• SMILES: CC1=NC(NC2=NC=C(C(NC3=C(C=CC=C3Cl)C)=O)S2)=CC(N4CCN(CC4)CCCNC(COC5=CC=C(C=C5)C6CCC(NC6=O)=O)=O)=N1
• Target: Others

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

168902020