rTRD01

• Catalog Number: orb1943513
• Category: Small Molecules
• Description: rTRD01 is a TDP-43 ligand that selectively binds to the RRM1 and RRM2 domains of TDP-43, exhibiting a dissociation constant (Kd) of 89 µM for TDP-43 102–269. The compound can partially disrupt the interaction between TDP-43 and the hexanucleotide RNA repeat associated with the c9orf72 gene, implicated in certain neurodegenerative diseases. rTRD01 holds potential for use in neurodegenerative disease research [1].
• CAS Number: 1332175-56-0
• Purity: 98.00%
• MW: 344.38
• SMILES: O=C(N)C=1N=C(C=NC1)N2CCCC(CO)(CC3=CC=C(F)C=C3)C2
• Formula: C₁₈H₂₁FN₄O₂
• Biological Activity: rTRD01 is a TDP-43 ligand that selectively binds to the RRM1 and RRM2 domains of TDP-43, exhibiting a dissociation constant (Kd) of 89 µM for TDP-43 102–269. This compound is capable of partially disrupting the interaction between TDP-43 and the hexanucleotide RNA repeat associated with the c9orf72 gene, which is implicated in certain neurodegenerative diseases. rTRD01 holds potential for use in neurodegenerative disease research [1].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.