Recombinant Human IL-15(hFc Tag)

SKU: orb1921846

Description

Interleukin (IL)-15 is a 14-15 kDa four-helix bundle cytokine. IL-15, unlike other cytokines, is widely expressed by many cell types including monocytes, macrophages, dendritic cells (DCs), fibroblasts, epithelial cells, and skeletal muscle cells, but surprisingly not by T cells. It acts as a growth factor and also promotes the survival of T, B, and NK cells by preventing apoptosis through the upregulation of anti-apoptotic and downregulation of pro-apoptotic factors. IL-15 plays a crucial role in the development, homeostasis, and function of T, NK, and NK-T cells, and is additionally required for various functions of the B cells, DCs, macrophages, and mast cells. IL-15 is minimally secreted but is effectively delivered by trans-presentation in association with its unique receptor alpha (IL-15 Rα) on the surface of IL-15 producing cells to interact with a receptor complex composed of the IL-2R β and common γ chains on target cells. Trans-presented IL-15/IL-15 Rα signals through β and γ chains expressed on responding cells, leading to the recruitment and activation of JAK1 and JAK3. Activated JAK1 and JAK3 further phosphorylate STAT3 and STAT5, which prompts the transcription of IL-15-modulated genes in effector cells.

Images & Validation

• Application Notes:
  Application Notes: For research use only. Minimum Sample Size: 50μg/vial

Key Properties

• Source: CHO Cell
• Expression System: Eukaryotic cell
• Biological Origin: Human
• Molecular Weight: 77.33 kDa
• Purity: ≥90%
• Endotoxins: ≤10 EU/mg

Storage & Handling

• Storage: Use a manual defrost freezer and avoid repeated freeze - thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1 month, 2 to 8°C under sterile conditions after reconstitution. 6 months, -20 to -77°C under sterile conditions after reconstitution.
• Form/Appearance: Lyophilized Powder
• Disclaimer: For research use only

Alternative Names

Interleukin 15

Quick Database Links

UniProt

P40933

NCBI Gene ID

3600