NO-Indomethacin

SKU: orb1693643

Description

NO-indomethacin is a nitric oxide-donating hybrid of indomethacin designed to retain anti-inflammatory and analgesic efficacy while mitigating the gastrointestinal and renal toxicity associated with conventional NSAIDs. It demonstrates significantly enhanced potency in vitro, such as inhibiting pancreatic cancer cell (PaCa-2) growth with an IC50 of 82 μM, and shows promise for chemoprevention research.

Key Properties

• CAS Number: 301838-28-8
• MW: 620.07
• Formula: C₂₈H₃₀ClN₃O₉S
• SMILES: COc1ccc2n(C(=O)c3ccc(Cl)cc3)c(C)c(CC(=O)SC[C@@H](NC(C)=O)C(=O)OCCCCON(=O)=O)c2c1
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

87785475