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Nexinhib20

SKU: orb1692053

Description

Nexinhib20 is a small molecule inhibitor of exosome biogenesis and transport, targeting RAB27A and nSMase2. It exhibits anti-inflammatory activity by suppressing neutrophil adhesion and β2 integrin activation through Rac1-GTP interaction antagonism, as demonstrated in vitro with human neutrophils.

Research Area

Immunology & Inflammation, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number331949-35-0
MW300.31
Purity99.89% (May vary between batches)
FormulaC15H16N4O3
SMILESO=C(C(C)(C)C)C(N1N=CN=C1)=CC2=CC=CC([N+]([O-])=O)=C2
TargetIntegrin,ROS,Ras,Reactive Oxygen Species
SolubilityEthanol:5 mg/mL (16.65 mM);DMSO:80 mg/mL (266.39 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.99 mM)

Storage & Handling

Storagekeep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Nexinhib20, Nexinhib-20

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Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Nexinhib20 (orb1692053)

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% DMSO +
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% Tween 80 +
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1 mg
$ 90.00
5 mg
$ 140.00
10 mg
$ 210.00
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