N-didesmethyl Loperamide

SKU: orb1979966

Description

N-didesmethyl Loperamide, an active metabolite of the peripheral μ1-opioid receptor agonist loperamide, impedes electrically induced contractions in isolated guinea pig myenteric plexus (IC50 = 370 nM) and enhances the sensitivity of a chloroquine-resistant P. falciparum strain to chloroquine (EC50 = 482 nM). Notably, it achieves this without causing toxicity in A-10 vascular smooth muscle cells (IC50 = >10,000 nM).

Key Properties

• CAS Number: 66164-06-5
• MW: 448.98
• Formula: C₂₇H₂₉ClN₂O₂
• SMILES: NC(C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3CCC(C4=CC=C(Cl)C=C4)(O)CC3)=O
• Target: Others

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

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