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MBX3135
Catalog Number: orb2565817
| Catalog Number | orb2565817 |
|---|---|
| Category | Small Molecules |
| Description | MBX3135, an efflux pump inhibitor, can enhance the efficacy of antibiotics by targeting the AcrB in bacteria. MBX3135 is applicable to research on infections and antibiotics. |
| MW | 506.66 |
| CAS Number | 1636878-36-8 |
| Formula | C28H34N4O3S |
| SMILES | C(#N)C1=C2C(=C(N=C1SCCC3=CC=C(NC(C=C)=O)C=C3)N4CC(C)OC(C)C4)COC(C)(C)C2 |
| Storage | -20°C |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
For example, if the dosage of your experiment is 10mg/kg, the weight of each animal is 50g, and the volume of the dosing is 100μL, then the working solution concentration of your experiment is 5mg/mL. If the formula you used is 5% DMSO+ 30% PEG300+ 5% Tween 80 + 60% Saline/PBS/ddH2O, the preparation method is as follows:
Mother liquor preparation method: 5mg of drug dissolved in 100μL DMSO (mother liquor concentration is 50mg/mL). Preparation method of in vivo formulation: For 1mL of working solution preparation, take 50μL of DMSO mother liquor, add 300 μL of PEG300 to mix well and clarify, then add 50μL of Tween-80 to mix well and clarify, and finally add 600μL of Saline/PBS/ddH2O to mix well and clarify.Note:
- For Reference Only. Please choose the appropriate dissolution protocol according to your experimental animal and administration method.
- We suggest that in cell experiments, the final concentration of DMSO is not more than 0.1%, in animal experiments, for healthy mice, the final concentration of DMSO is not more than 10%; For nude or frail mice, the final concentration of DMSO is not more than 2%.
