GSK2850163

SKU: orb1309602

Description

GSK2850163

Research Area

Cell Biology

Key Properties

• CAS Number: 2121989-91-9
• MW: 446.41
• Purity: 99.04%
• Formula: C₂₄H₂₉Cl₂N₃O
• SMILES: Cc1ccc(CNC(=O)N2CCC[C@]3(CCN(Cc4ccc(Cl)c(Cl)c4)C3)C2)cc1
• Target: IRE1
• Solubility: DMSO:110 mg/mL (246.41 mM);Ethanol:50 mg/mL (112 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.96 mM)

Bioactivity

• Target IC50:
  IRE1α RNase activity:200 nM |IRE1α kinase activity:20 nM
• In Vitro:
  The increased autophosphorylation of IRE1α could be reduced in a dose-dependent manner by GSK2850163. Increasing concentrations of GSK2850163 are capable of reducing the increased XBP 1 transcriptional activity. Two additional kinases are weakly inhibited by GSK2850163: Ron (IC50=4.4 μM) and FGFR1 V561M (IC50=17 μM).

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, IRE1α RNase activity, IRE1α, IRE1α kinase activity, IRE1, GSK2850163, GSK-2850163, GSK 2850163, Inhibitor, Inositol requiring enzyme 1

Compound Identifiers

PubChem CID

73291790