DP-15

SKU: orb2945051

Description

DP-15 acts as a degrader of GSPT1 and BRD4, with DC50 values of 5.25 nM and 0.48 nM, respectively. This compound exhibits antiproliferative activity in AML and NHL cells, showing IC50 values in the nanomolar range, induces G1 phase cell cycle arrest, and triggers apoptosis in MOLM13 cells. Additionally, DP-15 demonstrates anti-leukemic properties in the MOLM-13 xenograft mouse model. [Pink: ligand for target protein JQ-1 carboxylic acid; Black: linker; Blue: ligand for E3 ligaseCereblonThalidomide-5-OH]

Key Properties

• CAS Number: 3033837-71-4
• MW: 822.374
• Formula: C₄₂H₄₄ClN₉O₅S
• SMILES: CC=1C2=C(N3C([C@H](CC(=O)N4CCN(CC5CCN(CC5)C=6C=C7C(=CC6)C(=O)N(C7=O)C8C(=O)NC(=O)CC8)CC4)N=C2C9=CC=C(Cl)C=C9)=NN=C3C)SC1C
• Target: Epigenetic Reader Domain,PROTACs,Apoptosis

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Epigenetic Reader Domain,PROTACs,Apoptosis