Chroman 1

SKU: orb1308454

Description

Chroman 1 is a highly potent and selective small molecule inhibitor of ROCK kinases, exhibiting sub-nanomolar IC50 values of 52 pM for ROCK1 and 1 pM for ROCK2. It is a valuable research tool for investigating Rho/ROCK signaling pathways in cardiovascular, neurological, and fibrotic disease models, applicable in both cellular and biochemical assays.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1273579-40-0
• MW: 436.5
• Purity: 99.91% (May vary between batches)
• Formula: C₂₄H₂₈N₄O₄
• SMILES: COc1ccc2OC[C@H](Cc2c1)C(=O)Nc1ccc(cc1OCCN(C)C)-c1cn[nH]c1
• Target: ROCK
• Solubility: DMSO:50 mg/mL (114.55 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (7.56 mM)

Bioactivity

• Target IC50:
  MRCK:150 nM|ROCK1:52 pM|ROCK2:1 pM
• In Vitro:
  Chroman 1 also shows inhibitory activities against MRCK (IC50: 150 nM). However, it has no effect on PKA (IC50, > 20000 nM) or AKT1 (IC50, > 20000 nM).
  Read more...

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ROCK, ROCK1, ROK, ROCK2, Rho-kinase, rho kinase, Rho-associated protein kinase, Rho-associated kinase, spinal, inhibit, MRCK, glaucoma, injury, Inhibitor, cord, Chroman 1, Chroman1, Chroman-1

Compound Identifiers

PubChem CID

66577033