BAY-678

SKU: orb1710316

Description

BAY-678 is a potent, selective, and orally bioavailable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. Recommended as a chemical probe by the SGC, it is a valuable tool for investigating HNE's role in inflammatory and pulmonary diseases in both in vitro and in vivo research contexts.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 675103-36-3
• MW: 400.35
• Purity: 99.36% (May vary between batches)
• Formula: C₂₀H₁₅F₃N₄O₂
• SMILES: CC(=O)C1=C(C)N(C(=O)N[C@@H]1c1ccc(nc1)C#N)c1cccc(c1)C(F)(F)F
• Target: Others,Serine Protease
• Solubility: Ethanol:4.3 mg/mL (10.74 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (8.24 mM);DMSO:90 mg/mL (224.8 mM)

Bioactivity

• Target IC50:
  HNE:20 nM|MNE:700 nM(Ki)
• In Vivo:
  BAY-678 reveals significant efficacy in preclinical models of ALI and lung emphysema. Additionally, BAY-678 has shown significant beneficial pulmonary hemodynamic and vascular effects in models of PAH in rats and mice.
• In Vitro:
  BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium. The Ki value of BAY-678 for MNE is 700 nM. BAY-678 is the 4th generation inhibitor of HNE.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BAY 678, BAY678, BAY-678, HNE

Compound Identifiers

PubChem CID

23728722