Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2

SKU: orb2277241

Description

Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1) [a subtype of G-protein coupled receptors involved in mediating thrombin's cellular effects]. Exhibiting high specificity for PAR-1 over PAR-2, its selectivity was assessed via cell-based calcium signaling assays in HEK293 cells. As an agonist, it is instrumental for in vivo investigations of PAR-1 activation. PAR-1 also collaborates with PAR-4, influencing thrombin-induced hepatocellular carcinoma within [coagulation type] tumor environments where thrombin generation occurs.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 211190-38-4
• MW: 883.02
• Formula: C₄₂H₆₃FN₁₂O₈
• SMILES: [C@@H](CC1CCCCC1)(NC([C@@H](NC([C@H](CC2=CC=C(F)C=C2)NC([C@H](C)N)=O)=O)CCCNC(=N)N)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N)=O)=O)CCCNC(N)=O)=O
• Target: Protease-activated Receptor

Storage & Handling

• Storage: -20°C
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Protease-activated Receptor