Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2

• Catalog Number: orb2277241
• Category: Small Molecules
• Description: Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1) [a subtype of G-protein coupled receptors involved in mediating thrombin's cellular effects]. Exhibiting high specificity for PAR-1 over PAR-2, its selectivity was assessed via cell-based calcium signaling assays in HEK293 cells. As an agonist, it is instrumental for in vivo investigations of PAR-1 activation. PAR-1 also collaborates with PAR-4, influencing thrombin-induced hepatocellular carcinoma within [coagulation type] tumor environments where thrombin generation occurs.
• CAS Number: 211190-38-4
• Purity: 98.00%
• MW: 883.02
• SMILES: [C@@H](CC1CCCCC1)(NC([C@@H](NC([C@H](CC2=CC=C(F)C=C2)NC([C@H](C)N)=O)=O)CCCNC(=N)N)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N)=O)=O)CCCNC(N)=O)=O
• Formula: C₄₂H₆₃FN₁₂O₈
• Biological Activity: Ala-parafluoroPhe-Arg-Cha-Cit-Tyr-NH2 is a biologically active peptide functioning as a selective agonist for Protease Activated Receptor 1 (PAR-1), a subtype of G-protein coupled receptors involved in mediating thrombin's cellular effects. Exhibiting high specificity for PAR-1 over PAR-2, its selectivity was assessed via cell-based calcium signaling assays in HEK293 cells. As an agonist, it is instrumental for in vivo investigations of PAR-1 activation. PAR-1 also collaborates with PAR-4, influencing thrombin-induced hepatocellular carcinoma within 'coagulation type' tumor environments where thrombin generation occurs.
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.