ZD-0892

SKU: orb1708184

Description

ZD-0892 is a potent and selective neutrophil elastase inhibitor effective against both human and porcine pancreatic elastase. It has demonstrated efficacy in reversing advanced pulmonary vascular disease in rat models, making it a valuable research tool for studying COPD and peripheral vascular disease pathogenesis.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 171964-73-1
• MW: 499.52
• Purity: 99.53%
• Formula: C₂₄H₃₂F₃N₃O₅
• SMILES: COc1ccc(cc1)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
• Target: Serine Protease
• Solubility: DMSO:150 mg/mL (300.29 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (8.01 mM)

Bioactivity

• Target IC50:
  Neutrophil elastase (human):6.7 nM (Ki)|Neutrophil elastase (pig):200 nM (Ki)
• In Vivo:
  Administration of ZD0892 to DBA/2 mice infected with EMC virus reduces myocardial elastolytic activity and coronary microvascular perfusion injury.ZD0892 reduces the pathological severity of myocardial lesions associated with viral myocarditis in mice.ZD-0892 reverses advanced pulmonary vascular disease produced in rats.
• In Vitro:
  Neutrophils incubated with ZD-0892 (20µM) for 1 hour were found to be resistant to superoxide, hypochlorite, hydrogen peroxide, hydroxyl radical and peroxynitrite-mediated degradation and had no effect on the formation of these oxidants by activated neutrophils.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Human neutrophil elastase, neutrophil elastase, Serine Protease, SerineProtease, ZD 0892, ZD0892, ZD-0892

Compound Identifiers

PubChem CID

9892148