VRK-IN-1

SKU: orb1694253

Description

VRK-IN-1 is a potent and selective small molecule inhibitor of Vaccinia-Related Kinase 1 (VRK1). It serves as a valuable research tool for investigating VRK1's role in DNA damage response, cell cycle, and neurological disorders, enabling both in vitro and in vivo mechanistic studies.

Research Area

Protein Biochemistry

Key Properties

• CAS Number: 2378855-09-3
• MW: 349.28
• Purity: 99.25%
• Formula: C₁₈H₁₁F₄NO₂
• SMILES: Cc1ncc(cc1-c1cc(F)c(O)c(F)c1)-c1cc(F)c(O)c(F)c1
• Target: Serine Protease,Others
• Solubility: DMSO:80 mg/mL (229.04 mM);10% DMSO+90% Corn Oil:3.3 mg/mL (9.45 mM)

Bioactivity

• Target IC50:
  VRK1:150 nM (IC50)|VRK1:150 nM
• In Vitro:
  VRK-IN-1 (3.2 μM; 24 hours) slightly decreases the viability of human HeLa cells.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

VRK IN 1, VRKIN1, VRK-IN-1

Compound Identifiers

PubChem CID

155511407