Topterone

SKU: orb1708338

Description

Topterone (Win 17,665) is a potent topical antiandrogen used in research. It effectively blocks the action of testosterone and dihydrotestosterone, as demonstrated in studies of androgen-dependent organ growth in castrated immature male hamsters. This makes it a valuable tool for investigating androgen receptor pathways in dermatology and endocrine research.

Research Area

Metabolism Research

Key Properties

• CAS Number: 60607-35-4
• MW: 330.5
• Purity: >99.99% (May vary between batches)
• Formula: C₂₂H₃₄O₂
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)C(CC3)=CC(=O)CC4)(CC1)[H])[H])(CC[C@]2(CCC)O)[H]
• Target: Androgen Receptor

Bioactivity

• In Vivo:
  To determine its endocrine profile, Topterone is administered parenterally or topically to rats, rabbits, or hamsters. Systemic administration reveals that Topterone exhibits both antiandrogenic and progestational effects. However, topical application at a dose of 1 g/kg/day fails to induce a systemic antiandrogenic response, and only a minimal progestational response is observed at 32 mg/kg/day. No other endocrine activities are detected in these experiments. Topterone demonstrates the inhibition of flank organ development in castrated immature male hamsters in response to both testosterone and dihydrotestosterone, whereas Progesterone inhibits stimulation by only testosterone. Furthermore, topical application of Topterone has been shown to cause regression in the development of the flank organ.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Androgen, Androgen Receptor, AndrogenReceptor, Topterone, Win 17665

Compound Identifiers

PubChem CID

9797605