Tilmicosin

SKU: orb1310302

Description

Tilmicosin (EL-870) is a veterinary macrolide antibiotic primarily used to treat bovine and ovine respiratory disease caused by Mannheimia haemolytica. It is employed in research for studying antimicrobial mechanisms and efficacy in both in vitro susceptibility assays and in vivo animal infection models.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 108050-54-0
• MW: 869.13
• Purity: 99.50%
• Formula: C₄₆H₈₀N₂O₁₃
• SMILES: O([C@H]1[C@@H](CCN2C[C@@H](C)C[C@@H](C)C2)C[C@@H](C)C(=O)\C=C\C(\C)=C\[C@H](CO[C@H]3[C@H](OC)[C@H](OC)[C@H](O)[C@@H](C)O3)[C@@H](CC)OC(=O)C[C@@H](O)[C@@H]1C)[C@H]4[C@H](O)[C@@H](N(C)C)[C@H](O)[C@@H](C)O4
• Target: Antibacterial,Apoptosis,Antibiotic,Calcium Channel
• Solubility: DMSO:250 mg/mL (287.64 mM);H2O:8 mg/mL (9.2 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (2.3 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• In Vivo:
  After a subcutaneous injection, tilmicosin is eliminated more slowly from serum and milk, with t1/2 beta S of 29.3 and 41.4 hours, respectively. The apparent volume of distribution of tilmicosin is more than 1 L/kg. The peak serum tilmicosin concentration is 1.56 μg/mL. 6.39 hours after a subcutaneous injection of 10 mg/kg. Tilmicosin is extensively secreted into milk, reaching a maximum concentration of 11.6 μg/mL and having a large AUCmilk/AUCserum ratio of approximately 12:1. Tilmicosin is detectable in milk for 11 days after a single subcutaneous dose.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tilmicosin, EL870, EL-870, EL 870, Inhibitor, LY 177370, LY177370, LY-177370, inhibit, Bacterial, Antibiotic

Compound Identifiers

PubChem CID

5282521