T807

SKU: orb1306980

Description

T807 (AV-1451) is a tau PET imaging tracer used in neuroscience research. It enables the in vivo detection and quantification of neurofibrillary tau tangles, facilitating the study of Alzheimer's disease and other tauopathies in both preclinical and clinical experimental models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1415379-56-4
• MW: 263.27
• Purity: 99.72% (May vary between batches)
• Formula: C₁₆H₁₀FN₃
• SMILES: Fc1ccc(cn1)-c1ccc2c(c1)[nH]c1ccncc21
• Target: Microtubule Associated
• Solubility: DMSO:1 mg/mL (3.8 mM)

Bioactivity

• In Vivo:
  [18F]T807 can cross the blood-brain barrier and ished out quickly in mice models. [18F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan.
• In Vitro:
  In vitro autoradiography results show that [18F]T807 exhibits strong binding to PHF-tau positive human brain sections with Kd of 14.6 nM. Comparison of autoradiography and double immunohistochemical staining of adjacent sections of PHF-tau and Ab showed that [18F] T807 binding is colocalized with immunoreactive PHF-tau pathology, but does not highlight Ab plaques. [18F]T807 strongly binds to tau lesions primarily made of paired helical filaments in Alzheimer’s brains e.g. intra and extraneuronal tangles and dystrophic neurites. [18F]T807 off-target binding to neuromelanin- and melanin-containing cells and, to a lesser extent, to brain hemorrhagic lesions is identified.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, MicrotubuleAssociated, Microtubule Associated, inhibit, AV 1451, AV-1451, AV1451, TAU, T807, T-807, T 807

Compound Identifiers

PubChem CID

71059746