Ro3280

SKU: orb1305238

Description

Ro3280

Research Area

Cell Biology

Key Properties

• CAS Number: 1062243-51-9
• MW: 543.61
• Purity: 99.19%
• Formula: C₂₇H₃₅F₂N₇O₃
• SMILES: COc1cc(ccc1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1
• Target: PLK
• Solubility: Ethanol:27.2 mg/mL (50.04 mM);DMSO:27.2 mg/mL (50.04 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.68 mM)

Bioactivity

• Target IC50:
  DAPK1:100 nM (Kd)|GAK:87 nM (Kd)|FER:53 nM (Kd)|PLK1:3 nM|PTK2 (Protein Tyrosine Kinase 2):84 nM (Kd)|TTK:51 nM (Kd)|ALK:230 nM (Kd)|MYLK:170 nM (Kd)|DAPK3:70 nM (Kd)|CAMKK2:87 nM (Kd)|PTK2B (Protein Tyrosine Kinase 2B):130 nM (Kd)|CAMKK1:1100 nM (Kd)|RPS6KA6 (KinDom.2):560 nM (Kd)
• In Vivo:
  RO3280 exhibits antitumor activity across a variety of tumor cell lines, effectively inhibiting cancer cell proliferation. Specifically, it demonstrates potency against lung cancer cell line H82 (IC50=5 nM), colorectal cancer cell HT-29 (IC50=10 nM), breast cancer cell MDA-MB-468 (IC50=19 nM), prostate cancer cell PC3 (IC50=12 nM), and skin cancer cell A375 (IC50=70 nM).
• In Vitro:
  In nude mice implanted with HT-29 human colon tumors, RO3280 (40 mg/kg) was effective in inhibiting tumor cell proliferation.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, PLK1, PLK, Polo-like Kinase (PLK), Inhibitor, Ro5203280, Ro3280, RO-3280, Ro-3280, RO 3280

Compound Identifiers

PubChem CID

25015677