Reserpine hydrochloride

SKU: orb2944238

Description

Reserpine hydrochloride is a VMAT2 inhibitor that depletes catecholamine and serotonin stores, resulting in antihypertensive and antipsychotic effects. It is widely utilized in research to establish experimental models for studying depression, gastric ulcers, and neurotransmitter dynamics in both in vivo and in vitro systems.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 16994-56-2
• MW: 645.14
• Purity: 99.96%
• Formula: C₃₃H₄₁ClN₂O₉
• SMILES: C(OC)(=O)[C@H]1[C@]2(C[C@@]3(C4=C(C=5C(N4)=CC(OC)=CC5)CCN3C[C@]2(C[C@@H](OC(=O)C6=CC(OC)=C(OC)C(OC)=C6)[C@@H]1OC)[H])[H])[H].Cl
• Target: MRP,Monoamine Transporter,Potassium Channel,Autophagy
• Solubility: DMSO:40 mg/mL (62 mM);H2O:< 1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.1 mM)

Bioactivity

• In Vivo:
  In rats, Reserpine hydrochloride (0.2 mg/kg; i.p.; once daily for 14 days) was administered to induce a depression-like phenotype. 48 hours after withdrawal, reserpine significantly decreased immobility time and increased climbing behavior in the forced swim test, indicating adaptive changes in monoamine systems. In rats, Reserpine hydrochloride (5 mg/kg; i.p.; single dose) was used to examine neurotransmitter turnover, which significantly increased urinary levels of vanillylmandelic acid (VMA) and 5-hydroxyindoleacetic acid (5-HIAA), indicating enhanced catecholamine and serotonin metabolism. In rats, Reserpine hydrochloride (0.5–15 μg/kg; i.p.; single dose) was tested for its antihypertensive effect, which produced a dose-dependent reduction in blood pressure.
• In Vitro:
  In JB6 P+ and HepG2-C8 cells, Reserpine hydrochloride (2.5–10 μM; 7 days) was used to evaluate its regulatory effects on oxidative stress and epigenetic markers. Reserpine hydrochloride upregulated Nrf2, HO-1, and NQO1 protein expression, while downregulating mRNA levels of DNMT1, DNMT3a, and DNMT3b. In clinical isolates of Staphylococcus aureus, Reserpine hydrochloride (20 mg/L) was used to assess its ability to inhibit the NorA efflux pump, reduce the MIC of ciprofloxacin, and enhance its antibacterial efficacy.

Storage & Handling

• Storage: keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Reserpine Hydrochloride, Serpasil hydrochloride, Serpalan hydrochloride, Serpivite hydrochloride

Compound Identifiers

PubChem CID

21155894