Propargyl-PEG11-methane

SKU: orb1307313

Description

Propargyl-PEG11-methane is a polyethylene glycol (PEG) linker utilized in constructing PROTAC molecules for targeted protein degradation research. Its application facilitates the synthesis of bifunctional degraders for both in vitro biochemical assays and in vivo pharmacological studies.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2250411-18-6
• MW: 554.67
• Purity: ≥98% (May vary between batches)
• Formula: C₂₆H₅₀O₁₂
• SMILES: C(OCCOCCOCCOCCOCCOCC#C)COCCOCCOCCOCCOCCOC
• Target: PROTAC Linker

Bioactivity

• In Vitro:
  PROTACs consist of two ligands connected by a linker: one binds to an E3 ubiquitin ligase, and the other to the target protein. They leverage the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, PEGs, PROTAC Linker, PROTAC Linkers, PropargylPEG11methane, Propargyl-PEG-11-methane, Propargyl-PEG11-methane, Propargyl PEG11 methane, PROTACLinker

Compound Identifiers

PubChem CID

118988454