PFM03

SKU: orb1689406

Description

PFM03 is a potent small molecule inhibitor that selectively targets the Mre11 nuclease, reducing MRN complex endonuclease activity by 98%. It is a valuable research tool for studying DNA damage response, specifically in blocking hMRN-mediated endonucleolytic processing and nuclear export in both cellular and biochemical assays.

Research Area

Cell Biology

Key Properties

• CAS Number: 1558598-48-3
• MW: 293.4
• Purity: 99.81%
• Formula: C₁₄H₁₅NO₂S₂
• SMILES: C(=C\1/C(=O)N(C(CC)C)C(=S)S1)\C2=CC=C(O)C=C2
• Target: Endonuclease
• Solubility: DMSO:80 mg/mL (272.67 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (11.25 mM)

Bioactivity

• In Vitro:
  Treatment with 50–400 μM PFM03 for 30 minutes specifically inhibits the endonuclease activity of MRE11 . Treatment with 100 μM PFM03 for 30 minutes does not impair double-strand break (DSB) repair in G2-phase (CENPF⁺) cells . Treatment with 50 μM PFM03 for 8 hours increases non-homologous end joining (NHEJ) activity while suppressing homologous recombination (HR) in cells .

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PFM 03

Compound Identifiers

PubChem CID

165412593