PF-07265028

SKU: orb2815364

Description

PF-07265028 is a potent and selective HPK1 inhibitor (IC50 = 17 nM) that blocks its kinase activity to relieve immune suppression. This action enhances T-cell function and has shown potential in preclinical models to remodel the tumor microenvironment and promote anti-tumor immunity, supporting its investigation in immuno-oncology research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 2736458-30-1
• MW: 472.59
• Formula: C₂₆H₃₂N₈O
• SMILES: [C@H](CC)(N)C1=C2C(C(=O)N(C2)C=3N=C(C=CC3)C=4N5C(=NN4)CC[C@@H]5C)=CC(=N1)N6[C@H](C)CCC6
• Target: MAPK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

163557606