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LY2444296

SKU: orb1709223

Description

LY2444296

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1346133-11-6
MW408.44
Purity99.18%
FormulaC24H22F2N2O2
SMILESNC(=O)c1ccc(Oc2ccc(CN3CCC[C@H]3c3cccc(F)c3)cc2)c(F)c1
TargetOpioid Receptor
SolubilityEthanol:25.2 mg/mL (61.7 mM);DMSO:60 mg/mL (146.9 mM);Methanol:5 mg/mL (12.24 mM)

Bioactivity

Target IC50
κ opioid receptor:ki: ~1 nM
In Vivo
LY2444296 reduces anxiety-like and depressive-like behaviors, and CORT release, in rats tested after chronic extended access cocaine self-administration. In cocaine-naïve adult male Sprague Dawley rats, LY2444296 (3 mg/kg; i.p.) prevents behavioral and neuroendocrine effects caused by U69,593.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

FP3FBZ, Opioid Receptor, OpioidReceptor, kappa opioid receptor, KOPR, LY 2444296, LY2444296, LY-2444296

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Key Properties

No computed properties available.

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Protocol Information

LY2444296 (orb1709223)

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Available Sizes

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5 mg
$ 80.00
10 mg
$ 120.00