LY2365109 hydrochloride

SKU: orb1309460

Description

LY2365109 hydrochloride is a potent, selective inhibitor of the human glycine transporter 1 (hGlyT1a), demonstrating an IC50 of 15.8 nM in cellular uptake assays. This compound is a valuable research tool for investigating GlyT1 function in preclinical models of schizophrenia and cognitive disorders, both in vitro and in vivo.

Research Area

Neuroscience

Key Properties

• CAS Number: 1779796-27-8
• MW: 421.91
• Purity: 99.47%
• Formula: C₂₂H₂₈ClNO₅
• SMILES: Cl.CN(CCOc1ccc(cc1C(C)(C)C)-c1ccc2OCOc2c1)CC(O)=O
• Target: GlyT
• Solubility: DMSO:30 mg/mL (71.11 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.74 mM)

Bioactivity

• Target IC50:
  GlyT1 (human):15.8 nM nM
• In Vivo:
  LY2365109 hydrochloride increases seizure thresholds in mice.LY2365109 hydrochloride (0.3-30 mg/kg; p.o.) produces dose-dependent elevations in CSF levels of glycine.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

seizure, uptake, Inhibitor, hGlyT1, glycine, Glycine transporters, GlyT1, GlyT, Human, LY2365109 Hydrochloride, LY2365109 hydrochloride, LY-2365109 hydrochloride, LY-2365109 Hydrochloride, LY2365109, LY-2365109, LY 2365109, LY 2365109 Hydrochloride, inhibit, neuroblastoma

Compound Identifiers

PubChem CID

56972229