LR-90

SKU: orb1309470

Description

LR-90

Research Area

Immunology & Inflammation, Neuroscience

Key Properties

• CAS Number: 245075-84-7
• MW: 709.57
• Purity: 99.68%
• Formula: C₃₅H₃₄Cl₂N₄O₈
• SMILES: CC(C)(Oc1ccc(NC(=O)Nc2ccc(Cc3ccc(NC(=O)Nc4ccc(OC(C)(C)C(O)=O)cc4)c(Cl)c3)cc2Cl)cc1)C(O)=O
• Target: COX,Others
• Solubility: DMSO:95 mg/mL (133.88 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (4.65 mM)

Bioactivity

• In Vivo:
  LR-90 (50 mg/L) decreases renal AGE, AGER and lipid peroxidation.LR-90 (50 mg/L, p.o. for 27 weeks) significantly reduces plasma lipids, modestly affects hyperglycaemia in ZDF rats.
• In Vitro:
  LR-90 (0, 25, 50, 100, and 200 μM) significantly blocks THP-1 cell adherence to endothelial cells in a dose-dependent manner after 1-hour pretreatment followed by S100b stimulation for 24 hours, without affecting THP-1 cell viability. Additionally, LR-90 inhibits RAGE, MCP-1, COX-2, IP-10, and NOX2 mRNA expression in THP-1 cells dose-dependently after 1-hour pretreatment before S100b stimulation for 4 hours.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, LR 90, LR90, LR-90, Inhibitor, AGE

Compound Identifiers

PubChem CID

10212249