THR-β agonist 11

SKU: orb3173236

Description

THR-β agonist 11 is an orally active and selective thyroid hormone receptor (THR-β) agonist. It demonstrates robust cholesterol-lowering effects in cholesterol-fed rats. In a high-fat diet-carbon tetrachloride (HFD-CCl4) induced model of metabolic dysfunction-associated steatohepatitis (MASH) in mice, THR-β agonist 11 significantly reduces serum total triglycerides (TG), low-density lipoprotein cholesterol (LDL-cholesterol), liver total cholesterol (TC), and TG levels. Additionally, it alleviates hepatic steatosis, inflammation, and fibrosis. THR-β agonist 11 is applicable in the study of MASH and other fibrotic diseases.

Key Properties

• CAS Number: 3051970-23-8
• MW: 516.96
• Formula: C₂₆H₃₀ClN₂O₅P
• SMILES: C(OC1=CC(C)=C(CC=2C=C(C(C)C)C(=O)NN2)C(C)=C1)P3(=O)O[C@@H](CCO3)C4=CC(Cl)=CC=C4
• Target: Thyroid hormone receptor(THR)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Thyroid hormone receptor(THR)