Imidacloprid

SKU: orb1300302

Description

Imidacloprid is a systemic neonicotinoid insecticide widely used in agricultural pest control. It is a valuable research tool for studying insect neurobiology, both in vitro and in vivo, due to its action as a nicotinic acetylcholine receptor agonist.

Key Properties

• CAS Number: 138261-41-3
• MW: 255.66
• Purity: 99.97% (May vary between batches)
• Formula: C₉H₁₀ClN₅O₂
• SMILES: [O-][N+](=O)\N=C1/NCCN1CC1=CC=C(Cl)N=C1
• Target: Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (19.56 mM);DMSO:300 mg/mL (1173.43 mM)

Bioactivity

• In Vitro:
  Three different cell models were used; adipocytes (3T3-L1), hepatocytes (HepG2), and myotubes (C2C12). These cells were treated with imidacloprid (0, 10, and 20 μM) for 4-6 days followed by treatment with insulin for 15 min to determine responses. Insulin stimulated glucose uptake was reduced by imidacloprid in all three cell culture models. Treatment with imidacloprid reduced phosphorylation of protein kinase B (AKT), one of the major regulators of insulin signaling, without changing overall AKT expression. Subsequently, imidacloprid reduced phosphorylation of ribosomal S6 kinase (S6K), which is a downstream target of AKT and also a feed-back inhibitor of insulin signaling. Suggest that imidacloprid could induce insulin resistance by affecting the insulin signaling cascade, particularly up-stream of AKT, in adipocytes, liver, and muscle.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Imidacloprid, inhibit, Inhibitor

Compound Identifiers

PubChem CID

86287518