Acetylshikonin

SKU: orb1301243

Description

Acetylshikonin is a bioactive shikonin derivative that exhibits antiangiogenic and antitumor effects by inhibiting cell proliferation and NADPH oxidase assembly. It induces apoptosis in cancer cells via endoplasmic reticulum stress and Nur77 pathway modulation, while also demonstrating anti-inflammatory activity by suppressing mast cell degranulation in vivo.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Neuroscience

Key Properties

• CAS Number: 24502-78-1
• MW: 330.33
• Purity: 99.74% (May vary between batches)
• Formula: C₁₈H₁₈O₆
• SMILES: CC(C)=CC[C@@H](OC(C)=O)C1=CC(=O)c2c(O)ccc(O)c2C1=O
• Target: Antibacterial,Cholinesterase (ChE),Apoptosis,Cytochromes P450,Autophagy
• Solubility: DMSO:3.31 mg/mL (10.02 mM)

Bioactivity

• Target IC50:
  CYP450:1.4-4.0 μM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CYPs, Cytochrome P450, Cholinesterase (ChE), Acetylshikonin, AChE, Acetyl shikonin, Inhibitor, inhibit

Compound Identifiers

PubChem CID

479501