GNE-9815

SKU: orb1298003

Description

GNE-9815 is a highly selective RAF kinase inhibitor. It is used in preclinical research to target KRAS-mutant cancers, showing activity in both in vitro cellular assays and in vivo tumor models as part of combination therapeutic strategies.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 2729996-45-4
• MW: 455.48
• Purity: 99.10% (May vary between batches)
• Formula: C₂₆H₂₂FN₅O₂
• SMILES: Cc1cc(F)c(NC(=O)c2cccc(c2)C(C)(C)C#N)cc1-c1cnc2c(cnn(C)c2=O)c1
• Target: Ras,Kras,Raf
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.2 mM);DMSO:39.17 mg/mL (86 mM)

Bioactivity

• Target IC50:
  Raf:0.062 nM (Ki)|B-Raf:0.19 nM (Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Raf, KRAS, GNE9815, GNE-9815, GNE 9815, 3-(2-cyanopropan-2-yl)-N-[2-fluoro-4-methyl-5-(7-methyl-8-oxo-7,8-dihydropyrido[2,3-d]pyridazin-3-yl)phenyl]benzamide

Compound Identifiers

PubChem CID

155920128