Femoxetine

SKU: orb1819174

Description

Femoxetine is a serotonin reuptake inhibitor with antidepressant properties. It enhances morphine's analgesic effects and inhibits monoamine oxidases A and B, which are linked to physical performance in murine models. This compound is used in neuroscience research, particularly in studies of pain, depression, and neuropharmacology.

Research Area

Metabolism Research, Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 59859-58-4
• MW: 311.42
• Purity: 99.35%
• Formula: C₂₀H₂₅NO₂
• SMILES: C(OC1=CC=C(OC)C=C1)[C@@H]2[C@H](CCN(C)C2)C3=CC=CC=C3
• Target: 5-HT Receptor,MAO
• Solubility: DMSO:50 mg/mL (160.55 mM)

Bioactivity

• In Vivo:
  In 11 patients, Femoxetine (300 mg; daily) decreased blood serotonin from 0.17 +/- 0.06 microgram/ml (mean +/- SD) to 0.06 +/- 0.02 microgram/ml. In 8 patients treated with 300 mg femoxetine daily for 12 weeks, 14C-serotonin uptake into platelets in vitro was reduced significantly. Unlike most drugs used in migraine prophylaxis, femoxetine did not influence platelet aggregation in vitro.

Storage & Handling

• Storage: Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

5-HT, 5HTReceptor, 5HT Receptor, MAO-A, MAO-B

Compound Identifiers

PubChem CID

3012003