dWIZ-1

SKU: orb2646254

Description

dWIZ-1 ((rac)-dWIZ-1) is a cereblon-recruiting molecular glue that induces degradation of the WIZ protein. This degradation leads to fetal hemoglobin (HbF) induction in erythroblasts, making it a valuable research tool for studying sickle cell disease mechanisms in both cellular and animal models.

Research Area

Epigenetics & Chromatin, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 2879251-63-3
• MW: 399.48
• Purity: 92.87%
• Formula: C₂₂H₂₉N₃O₄
• SMILES: O=C1C2=CC=C(OC(C)C3N(CC)CCCC3)C=C2CN1C4C(=O)NC(=O)CC4
• Target: Others,PROTACs,Molecular Glues,Histone Acetyltransferase

Bioactivity

• Target IC50:
  Wiz:0.36 μM (DC₅₀)
• In Vitro:
  dWIZ-1 (Example 2) is a potent inhibitor of Wiz protein, with a DC₅₀ of 0.36 μM. dWIZ-1 is a useful tool compound for investigating genetic blood diseases, including hemoglobin-related disorders like sickle cell anemia and beta-thalassemia.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(rac)-dWIZ-1

Compound Identifiers

PubChem CID

156500565