DETA NONOate

SKU: orb1694096

Description

DETA NONOate (NOC 18) is a nitric oxide-releasing compound used as a research tool to study NO signaling. Its vasodilatory and potential neuroactive properties make it applicable for cardiovascular and neurological research, including in vitro neuronal studies and in vivo wound healing models.

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 146724-94-9
• MW: 163.18
• Purity: 99.60% (May vary between batches)
• Formula: C₄H₁₃N₅O₂
• SMILES: ON(N=O)N(CCN)CCN
• Target: NO Synthase
• Solubility: aqueous buffers:>100 mg/mL;H2O:30 mg/mL (183.85 mM);1M NaOH:120 mg/mL (735.38 mM);DMSO:<1 mg/mL (Insoluble)

Bioactivity

• In Vivo:
  DETA NONOate (15-150 μg/rat, intracerebroventricular injection, once) activates nociceptors in the formalin model in rats and, at 1 µM, reduces ischemia or ischemia/reperfusion-induced mitochondrial damage in the heart while preventing apoptotic cell death.
• In Vitro:
  By reducing the expression of glycopeptidolipids (GPL) in M. abscessus subspecies abscessus (Mab), DETA NONOate (100 μM; 16 h) induces the growth of nontuberculous mycobacteria (NTM) complex in the R morphotype.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Diethylamine NONOate, DETA NONOate, NOSynthase, NOC-18, NO Synthase

Compound Identifiers

PubChem CID

135409012