Dalzanemdor

SKU: orb1687204

Description

Dalzanemdor (SAGE-718) is a positive allosteric modulator of the NMDA receptor. It is utilized in preclinical research to investigate cognitive dysfunction associated with neurological disorders such as Huntington's disease and Alzheimer's disease, employing both in vitro and in vivo experimental models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1629853-48-0
• MW: 456.62
• Purity: >99.99% (May vary between batches)
• Formula: C₂₇H₄₃F₃O₂
• SMILES: C[C@@]12[C@@]3([C@]([C@]4([C@](C)(CC3)[C@@]([C@@H](CC[C@]([C@@](F)(F)F)(C)O)C)(CC4)[H])[H])(CC=C1C[C@@](C)(O)CC2)[H])[H]
• Target: iGluR,NMDAR
• Solubility: chloroform:5.68 mg/mL (12.44 mM)

Bioactivity

• In Vivo:
  SAGE-718 (Dalzanemdor) (5), a potent and high intrinsic activity NMDAR PAM with an optimized pharmacokinetic profile for oral dosing. Compound 5 has completed phase 1 single ascending dose and multiple ascending dose clinical trials and is currently undergoing phase 2 clinical trials for the treatment of cognitive impairment in Huntington's disease.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Dalzanemdor, iGluR, NMDA receptor, SAGE 718, SAGE718, SAGE-718

Compound Identifiers

PubChem CID

86305217