CCT020312

SKU: orb1707487

Description

CCT020312

Research Area

Cell Biology

Key Properties

• CAS Number: 324759-76-4
• MW: 650.4
• Purity: 98.63%
• Formula: C₃₁H₃₀Br₂N₄O₂
• SMILES: CCN(CC)CCC(=O)N1N=C(CC1c1ccc(Br)cc1)c1c(-c2ccccc2)c2cc(Br)ccc2[nH]c1=O
• Target: Autophagy,PERK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (6.15 mM);DMSO:145 mg/mL (222.94 mM)

Bioactivity

• In Vivo:
  METHODS: CCT020312 (2 mg/kg, intraperitoneal injection, starting at 17 weeks for 6 weeks) was used to treat P301S tau transgenic mice to test for mouse-specific visuospatial memory deficits. RESULTS P301S tau transgenic mice performed significantly better in the Morris water maze.
• In Vitro:
  METHODS: CCT020312 (0-9 µM, 24 h) treated medium HT29 cells for 24 h. Ser608 pRB phosphorylation was quantified using a cell-based immunoassay. RESULTS Concentration-dependent loss of P-S608-pRB signaling was observed with linear response values between 1.8 and 6.1 µM.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CCT020312, CCT-020312, CCT 020312, EIF2AK3/PERK

Compound Identifiers

PubChem CID

3108148