BMS-688521

SKU: orb1707534

Description

BMS-688521 is a potent, orally bioavailable small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1) that blocks its interaction with ICAM-1. This inhibitor has demonstrated anti-inflammatory activity in research, showing efficacy in both cellular adhesion assays and animal models of inflammation.

Research Area

Signal Transduction

Key Properties

• CAS Number: 893397-44-9
• MW: 536.37
• Purity: 98.87% (May vary between batches)
• Formula: C₂₆H₁₉Cl₂N₅O₄
• SMILES: O=C1[C@@]2([C@@H](CN(C2)C3=CC=C(C(O)=O)C=N3)C4=CC=C(C#N)C=C4)N(C)C(=O)N1C5=CC(Cl)=CC(Cl)=C5
• Target: Integrin
• Solubility: 10% DMSO+90% Corn Oil:5 mg/mL (9.32 mM);DMSO:80 mg/mL (149.15 mM)

Bioactivity

• Target IC50:
  ICAM1:78 nM
• In Vivo:
  In BALB/c female mice, 6-8 weeks of age (OVA Lung Inflammation in Mice), BMS-688521 (1, 3, and 10 mg/kg; p.o.; BID for three days) exhibited significant inhibition of eosinophil accumulation at a dose of 1 mg/kg BID, with dose-dependent inhibition observed at 3 mg/kg and 10 mg/kg.
• In Vitro:
  BMS-688521 inhibits the specific adhesion of mouse splenocytes and a mouse ICAM-1 expressing cell line, b.END3, with an IC50 of 78 nM.

Storage & Handling

• Storage: store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

BMS 688521, BMS688521, BMS-688521, ICAM-1, LFA-1

Compound Identifiers

PubChem CID

11699447