Befetupitant

SKU: orb1707578

Description

Befetupitant

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 290296-68-3
• MW: 565.55
• Purity: 98.72%
• Formula: C₂₉H₂₉F₆N₃O₂
• SMILES: N(C(C(C)(C)C1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)=O)(C)C=2C(=CC(=NC2)N3CCOCC3)C4=C(C)C=CC=C4
• Target: Neurokinin receptor
• Solubility: DMSO:6.88 mg/mL (12.17 mM)

Bioactivity

• In Vivo:
  In the alkali burn model, Befetupitant, a highly selective NK1R antagonist, was tested. Hemangiogenesis and lymphangiogenesis were effectively reduced (P<0.05) after topical application of Befetupitant for 4 days at both concentrations (0.4 and 1.6 mg/mL). However, both Befetupitant and its vehicle DMSO induced corneal opacity even in healthy controls, as observed during slit-lamp examination. Furthermore, fluorescein and hematoxylin-eosin staining confirmed DMSO toxicity by revealing epithelial damage and inflammatory cellular infiltration in the stroma. Despite Befetupitant's effectiveness in reducing corneal neovascularization (CNV) in the alkali burn model, its toxicity due to the DMSO vehicle led to the decision not to test it in the suture model.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Ro67-5930, NK1R, NK1, Neurokininreceptor, Neurokinin receptor, Befetupitant

Compound Identifiers

PubChem CID

6450815