Anandamide

SKU: orb1308719

Description

Anandamide is an endogenous cannabinoid and immune modulator that acts through cannabinoid receptors (CB1/CB2) and other targets like GPR18/GPR55. It is widely used in neuroscience and immunology research to study endocannabinoid signaling in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Metabolism Research, Molecular Biology, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 94421-68-8
• MW: 347.53
• Purity: 99.22%
• Formula: C₂₂H₃₇NO₂
• SMILES: CCCCCC=CCC=CCC=CCC=CCCCC(=O)NCCO
• Target: PPAR,Cannabinoid Receptor,Antifungal,Endogenous Metabolite,Microtubule Associated,TRP/TRPV Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.75 mM);DMSO:55 mg/mL (158.26 mM);Ethanol:10 mg/mL (28.77 mM)

Bioactivity

• In Vivo:
  Anandamide is an endocannabinoid binding both CB1R and CB2R. To evaluate the impact of CBR activation on whole-body glucose homeostasis, glucose tolerance is assessed after a single intraperitoneal Anandamide injection (10 mg/kg). The increase in glycemia in response to glucose ingestion is considerably smaller in mice treated with Anandamide compared with control. It is associated with an improvement of glucose tolerance as illustrated by the AUC0-2h calculations.
• In Vitro:
  Anandamide, acting via CB2 receptors, alleviates lipopolysaccharide (LPS)-induced neuroinflammation in rat primary microglial cultures. Endocannabinoids, especially Anandamide (AEA), can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55 .

Storage & Handling

• Storage: store at low temperature,store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EndogenousMetabolite, endocannabinoid, Endogenous Metabolite, GPR55, GPR18/GPR55, G protein-coupled receptor 55, Fungal, Human Endogenous Metabolite, hVSMC, HeLa cells, Inhibitor, inhibit, N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide, cervical epithelial cells, CB2, CB1, Candida albicans, Cannabinoid Receptor, CannabinoidReceptor, anti-adhesive, anti-fungal, Anandamide, (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide, Alzheimer's disease, PPAR, Peroxisome proliferator-activated receptors, Streptozotocin, Tau Protein, Transient receptor potential channels, TRP Channel

Compound Identifiers

PubChem CID

2185