AJI-100

SKU: orb2665557

Description

AJI-100 is a potent dual inhibitor of Aurora A kinase (IC50=12.7 nM) and JAK2 (IC50=18.5 nM). It disrupts T cell mitosis and polarity via Aurora A and reduces STAT3 phosphorylation via JAK2, thereby suppressing TH1/TH17 differentiation. This compound is a valuable research tool for studying immune regulation and GVHD in experimental models.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 844435-10-5
• MW: 323.32
• Formula: C₁₇H₁₄FN₅O
• SMILES: O=C(N)C1=CC=C(C=C1)NC2=NC=C(F)C(=N2)NC=3C=CC=CC3
• Target: JAK,STAT,Aurora Kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

86030571