8-Epidiosbulbin E acetate

SKU: orb1297476

Description

8-Epidiosbulbin E acetate

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 91095-48-6
• MW: 388.41
• Purity: 98.30%
• Formula: C₂₁H₂₄O₇
• SMILES: [H][C@@]12C[C@@]([H])(C(=O)O1)[C@@]1([H])[C@H](C[C@@]3([H])C(=O)O[C@@H](C[C@@]3(C)[C@]1([H])C2)c1ccoc1)OC(C)=O
• Target: Anti-infection,Antibacterial
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.15 mM);DMSO:55 mg/mL (141.6 mM)

Bioactivity

• In Vitro:
  A novel plasmid-curing compound was identified as 8-Epidiosbulbin E acetate (EEA) (norditerpene) on the basis of modern spectroscopic analysis and X-ray crystallography. EEA exhibited broad-spectrum plasmid-curing activity against multidrug-resistant (MDR) bacteria, including vancomycin-resistant enterococci. EEA cured antibiotic resistance plasmids (R-plasmids) from clinical isolates of Enterococcus faecalis, Escherichia coli, Shigella sonnei and Pseudomonas aeruginosa with 12-48% curing efficiency. The reference plasmids of Bacillus subtilis (pUB110), E. coli (RP4), P. aeruginosa (RIP64) and Salmonella typhi (R136) were cured with efficiency ranging from 16% to 64%. EEA-mediated R-plasmid curing decreased the minimal inhibitory concentration of antibiotics against MDR bacteria, thus making antibiotic treatment more effective.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

8-Epidiosbulbin E, 8Epidiosbulbin E acetate, 8-Epidiosbulbin E Acetate, 8 Epidiosbulbin E acetate, Bacterial, Antiinfection, Anti-infection, Antifection, inhibit, Inhibitor

Compound Identifiers

PubChem CID

139035029