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MBP Antibody / Myelin Basic Protein

Catalog Number: orb699550

DispatchUsually dispatched within 5-10 working days
$ 410.00
Catalog Numberorb699550
CategoryAntibodies
DescriptionMyelin basic protein (MBP) is the second most abundant protein in central nervous system (CNS) myelin: it comprises 30% of the total protein and about 10% of the dry weight of myelin. It is the only structural protein found so far to be essential for formation of CNS myelin, and has been called the executive molecule of myelin . MBP can interact with a number of polyanionic proteins including actin, tubulin, calmodulin, and clathrin, and negatively charged lipids, and acquires structure on binding to them. It may act as a membrane actin-binding protein, which might allow it to participate in transmission of extracellular signals to the cytoskeleton in oligodendrocytes and tight junctions in myelin. MBP may be applicable as a marker for oligodendrogliomas.
Species/HostMouse
ClonalityRecombinant
Clone NumberrMBP/4288
Tested applicationsIHC-P, WB
ReactivityHuman
IsotypeMouse IgG2a, kappa
ImmunogenA portion of amino acids 150-250 from the human protein was used as the immunogen for the recombinant MBP antibody.
Antibody TypePrimary Antibody
Dilution rangeWestern blot: 2-4ug/ml,Immunohistochemistry (FFPE): 1-2ug/ml for 30 minutes at RT
PurityProtein G affinity chromatography
ConjugationUnconjugated
Formula0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Hazard InformationThis recombinant MBP antibody is available for research use only.
UniProt IDP02686
StorageStore the recombinant MBP antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
Buffer/Preservatives0.2 mg/ml in 1X PBS with 0.1 mg/ml rAlbumin (US sourced), 0.05% sodium azide
NoteFor research use only
Application notesOptimal dilution of the recombinant MBP antibody should be determined by the researcher.
Expiration Date12 months from date of receipt.
MBP Antibody / Myelin Basic Protein

IHC staining of FFPE human cerebellum with recombinant MBP antibody (clone rMBP/4288). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

MBP Antibody / Myelin Basic Protein

IHC staining of FFPE human cerebellum with recombinant MBP antibody (clone rMBP/4288). HIER: boil tissue sections in pH9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

MBP Antibody / Myelin Basic Protein

Western blot testing of human brain lysate with recombinant MBP antibody (clone rMBP/4288). Isoforms may be visualized from 20~37 kDa.

MBP Antibody / Myelin Basic Protein

SDS-PAGE analysis of purified, BSA-free recombinant MBP antibody (clone rMBP/4288) as confirmation of integrity and purity.

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    Human

    Mouse

    Monoclonal

    Unconjugated

    20 μg
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    IHC-P,  WB

    Human

    Mouse

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  • MBP Antibody / Myelin Basic Protein [orb699743]

    IHC-P,  WB

    Human, Mouse

    Rat

    Monoclonal

    Unconjugated

    20 μg