(Z)-Leukadherin-1

SKU: orb1708192

Description

(Z)-Leukadherin-1

Research Area

Immunology & Inflammation

Key Properties

• CAS Number: 2055362-72-4
• MW: 421.49
• Purity: 99.23%
• Formula: C₂₂H₁₅NO₄S₂
• SMILES: C(\C=1OC(=CC1)C2=CC=C(C(O)=O)C=C2)=C\3/C(=O)N(CC4=CC=CC=C4)C(=S)S3
• Target: Complement System
• Solubility: DMSO:4 mg/mL (9.49 mM)

Bioactivity

• In Vivo:
  (Z)-Leukadherin-1 shows a mean half-life of 4.68 and 3.95 h, a maximum concentration of 1716 and 2594 ng/ml and AUC(0-t) in the plasma of 6950 and 13962 ng·h/ml at 30 and 100 mg/kg dosing, respectively. In KPC mice, (Z)-Leukadherin-1 (30, 60, or 120 mg/kg; gavage) delayes tumor progression and leads to a significantly decreased tumor burden in time-point analysis and improved overall survival.
• In Vitro:
  (Z)-Leukadherin-1 (4 μM) treatment reduces the numbers of total tumor-infiltrating CD11b+ cells and subsets of CD11b+ monocytes, eosinophils, granulocytes, and macrophages. (Z)-Leukadherin-1 leads to the repolarization of tumor-associated macrophages, reduction in the number of tumor-infiltrating immunosuppressive myeloid cells, and enhances dendritic cell responses.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(Z)Leukadherin1, (Z) Leukadherin 1, allosteric, ADH503, ADH-503, ADH-503 free base, ADH 503, Complement System, ComplementSystem, CD11b, dendritic, immunosuppressive, inhibit, orally, macrophages, Inhibitor, Leukadherin-1, repolarization, tumor-infiltrating, tumorassociated

Compound Identifiers

PubChem CID

5342077