XE 991 dihydrochloride

SKU: orb1307601

Description

XE 991 dihydrochloride is a potent and selective blocker of Kv7 (KCNQ) potassium channels, including Kv7.1, Kv7.2, and Kv7.2/7.3 heteromers, with IC50 values ranging from 0.6 to 0.98 μM. It is widely used in neuroscience research to inhibit the neuronal M-current, facilitating studies of neuronal excitability, synaptic plasticity, and related neurological disorders in both in vitro and in vivo models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 122955-13-9
• MW: 449.37
• Purity: 98.96%
• Formula: C₂₆H₂₂Cl₂N₂O
• SMILES: Cl.Cl.O=C1c2ccccc2C(Cc2ccncc2)(Cc2ccncc2)c2ccccc12
• Target: Potassium Channel
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:0.5 mg/mL (1.11 mM);DMSO:12 mg/mL (26.7 mM)

Bioactivity

• Target IC50:
  Kv7.2 channel:0.71 μM|Kv7.2/Kv7.3 channel:0.6 μM|Kv7.1 channel:0.75 μM|M-current:0.98 μM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

KcsA, inhibit, Kv7.1, Kv7.1 channel, Kv7.2 (KCNQ2) channels, Kv7.2 + Kv7.3 channel, Kv7.2 channel, Inhibitor, M-current, Potassium Channel, PotassiumChannel, XE 991, XE 991 Dihydrochloride, XE 991 dihydrochloride, XE991, XE-991, XE991 Dihydrochloride, XE-991 Dihydrochloride

Compound Identifiers

PubChem CID

45073462