Tryptophan-cholic acid

SKU: orb3027381

Description

Tryptophan-cholic acid (Trp-CA) is a microbial amino acid-binding bile acid (MABA), serving as an endogenous ligand and agonist for MRGPRE (Mas-related GPCR family member E), thereby inducing GLP-1 secretion. Tryptophan-cholic acid improves glucose tolerance in diabetic mice and may be utilised for studies on type 2 diabetes.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1630745-39-9
• MW: 594.78
• Purity: 100.00%
• Formula: C₃₅H₅₀N₂O₆
• SMILES: O[C@H]1[C@]2([C@]3([C@@](C)([C@@]([C@@H](CCC(N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(O)=O)=O)C)(CC3)[H])[C@@H](O)C[C@@]2([C@]6(C)[C@](C1)(C[C@H](O)CC6)[H])[H])[H])[H]
• Target: Endogenous Metabolite,GPCR
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (5.55 mM);DMSO:80 mg/mL (134.5 mM)

Storage & Handling

• Storage: keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Trp-CA

Quick Database Links

Gene Symbol

Endogenous Metabolite,GPCR