Tryptanthrin

SKU: orb1299508

Description

Tryptanthrin is a natural product that acts as a DNA gyrase inhibitor. It is used in biochemical research to study bacterial replication and has shown antibacterial activity in both in vitro assays and in vivo infection models.

Research Area

Cell Biology, Immunology & Inflammation, Molecular Biology, Neuroscience, Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 13220-57-0
• MW: 248.24
• Purity: 99.94% (May vary between batches)
• Formula: C₁₅H₈N₂O₂
• SMILES: O=C1N2C(C(=O)C=3C2=CC=CC3)=NC=4C1=CC=CC4
• Target: NF-κB,Interleukin,TNF,NO Synthase,DNA gyrase,Leukotriene Receptor,COX
• Solubility: Ethanol:< 1 mg/mL (insoluble);DMSO:5 mg/mL (20.14 mM);PBS:< 1 mg/mL (insoluble)

Bioactivity

• Target IC50:
  Leukotriene (human whole blood):10 µM (IC50)
• In Vivo:
  Tryptanthrin suppresses angiogenesis in vivo
• In Vitro:
  Tryptanthrin blocks signaling through VEGFR2 at the level of ERK1/2 signaling in vitro

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TNF Receptor, TNFR, Tumor Necrosis Factor Receptor, Tryptanthrin, anticancer, DNA gyrase, DNAgyrase, COX, Cyclooxygenase, Leukotriene biosynthesis, Leukotriene Receptor, MCF-7 cells, Interleukin Related, NO Synthase, Nuclear factor-kappaB, Nuclear factor-κB, Nitric oxide synthases, NF-κB, NOS, Inhibitor, inhibit, indole quinazoline, indigo-bearing plants

Compound Identifiers

PubChem CID

73549