Triptonide

SKU: orb1301306

Description

Triptonide (PG 492) is a bioactive small molecule with demonstrated efficacy in autoimmune disease models and potent antileukemic activity. Its anti-inflammatory function involves upregulating IL-37, a process modulated by ERK1/2 and p38 MAPK signaling pathways, as shown in cellular research.

Research Area

Cell Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 38647-11-9
• MW: 358.39
• Purity: 99.64% (May vary between batches)
• Formula: C₂₀H₂₂O₆
• SMILES: CC(C)C12OC1C1OC11C3(OC3CC3C4=C(CCC13C)C(=O)OC4)C2=O
• Target: Autophagy,Wnt/beta-catenin,Apoptosis
• Solubility: DMSO:50 mg/mL (139.51 mM)

Bioactivity

• Target IC50:
  Wnt:0.3 nM (IC50)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

lymphoma, Lyn, NSC165677, NSC-165677, inhibit, Inhibitor, NSC 165677, ERK, Hook F., beta-catenin, betacatenin, Beta catenin, anti-cancer, Autophagy, Apoptosis, bcatenin, wilfordii, Wnt, PG-492, PG492, PG 492, Wnt/b-catenin, Wnt/betacatenin, Wnt/β-catenin, β-catenin, βcatenin, Tripterygium, Triptonide

Compound Identifiers

PubChem CID

434304