Treprostinil diethanolamine

SKU: orb1686694

Description

Treprostinil diethanolamine (UT-15C) is a potent EP2, DP1, and IP receptor agonist, with EC50 values in the nanomolar range. Its activation of these receptors elevates intracellular cAMP, promoting vasodilation, particularly in human pulmonary arteries, and supports vascular homeostasis. This mechanism underpins its research utility in studying pulmonary hypertension and vascular biology in both in vitro and in vivo models.

Research Area

Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 830354-48-8
• MW: 495.65
• Purity: 99.86% (May vary between batches)
• Formula: C₂₇H₄₅NO₇
• SMILES: N(CCO)CCO.C(C[C@H](CCCCC)O)[C@@H]1[C@@]2([C@@](CC=3C(C2)=CC=CC3OCC(O)=O)(C[C@H]1O)[H])[H]
• Target: Prostaglandin Receptor
• Solubility: DMSO:5.5 mg/mL (11.1 mM)

Bioactivity

• Target IC50:
  IP:32.1 nM (Ki)|EP4:826 nM (Ki)|EP1:212 nM (Ki)|EP3:2505 nM (Ki)|EP2:3.6 nM (Ki)|FP:4680 nM (Ki)|DP1:4.4 nM (Ki)

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Prostaglandin Receptor, ProstaglandinReceptor, UT-15C, Treprostinil diethanolamine, DP1, IP, EP2

Compound Identifiers

PubChem CID

11179459