TRAP-6

SKU: orb1299649

Description

TRAP-6 (Thrombin Receptor Activator Peptide 6)(2TFA) is a selective agonist for Protease-Activated Receptor 1 (PAR1). It is widely used in cardiovascular and thrombosis research to study platelet activation and endothelial cell signaling in both in vitro and in vivo experimental models.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 141136-83-6
• MW: 748.87
• Purity: >99.99% (May vary between batches)
• Formula: C₃₄H₅₆N₁₀O₉
• SMILES: CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(O)=O
• Target: Protease-activated Receptor
• Solubility: DMSO:252.5 mg/mL (337.17 mM);H2O:33.33 mg/mL (44.51 mM)

Bioactivity

• Target IC50:
  PAR1:96 nM
• In Vitro:
  For analysis, platelet aggregometry was performed and the influence of epinephrine, adenosine diphosphate, collagen (Coll) and thrombin receptor-activated peptide (TRAP-6) as agonist were determined. Compared to the control group, patients with venous thromboembolism showed an enhanced maximal platelet aggregation with low concentrations of TRAP-6 (2 microM) and collagen (0.05 microM)

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

activating, platelets, PAR1, PAR-1, PAR-1 agonist peptide, Thrombin Receptor Activator Peptide-6, thrombin, Thrombin Receptor Activator Peptide 6, Thrombin Receptor Activator Peptide6, protease, Proteaseactivated Receptor, Protease-Activated Receptor (PAR), ProteaseactivatedReceptor, TRAP6, TRAP-6, TRAP 6

Compound Identifiers

PubChem CID

9831933